The work will consist in developing coarse-grained models of the cytoplasm to help discriminate between the various mechanisms that have been proposed to rationalize the compaction of the bacterial DNA inside the nucleoid. Since we have recently suggested that demixing between DNA and ribosomes may drive compaction, special attention will be paid to modeling adequately DNA, RNA, the ribosomes, as well as their respective interactions. It is hoped that a detailed understanding of the compaction and of the recent microscopy experiments with sub-wavelength resolution will emerge from the simulations.
Contact : Marc Joyeux
Email : email@example.com
Phone : 04 76 51 47 51