Cells interact both mechanically and via biochemical signals with their local environment, which is constituted of other cells. Understanding the bidirectional transduction of a mechanical force into a biochemical signal (and a biochemical signal into a mechanical response) is essential to determine how the cell/environment crosstalk affects cell division, death, motility, polarization, but also the supra-cellular organization.
From a mechanical point of view, we progressively scale up from a single cell to three dimensional aggregate of mutually interacting cells, in order to clarify the relationships between physical environment, cell mechanics and cellular response. At the organ level, we investigate the complex structure of bones to identify how the hierarchical organization and the ultrastructure determine the biomechanical properties and the development of bones. The research activity includes the study of the role and function of calcium channels in neuronal structures.