Optical microscopy in biology develops today along two major directions:
improving imaging quality, especially in terms of resolution and 3D field of view;
and improving content and quantitativeness of associated measurements, such as molecular concentration and dynamics.
In the past, Adaptive Optics (AO) approaches have been successfully used in microscopy for correcting sample-induced aberrations,
but the majority of these methods have been concerned with compensating low-order aberrations which arise in rather transparent samples
or at shallow focusing depth. However, when focusing deep into a specimen (tens to hundreds of µm), large-amplitude aberrations with complex phase structure arise
and light scattering dramatically increases. In our project, we will investigate how to take these effects into account and what are the most efficient correction schemes
and strategies for FFM. Complementary experiments and numerical / theoretical calculations will be conducted by the Grenoble and Göttingen partners, which will imply visits between the two groups.
We are looking of a post-doctoral researcher to join the Grenoble group: the contract should begin in September or October 2017 for a total duration up to 30 months.