We propose to track the cells position inside a growing tumor in 3D and in real time. Based on those experimental observations, we will build up a theoretical description of the tumor as an “active material” and a predictive model to describe the cellular motion inside the tumor tissue.
Task 1 : Observe in real time the local rearrangement of cells, inside a model tumor submitted to a mechanical perturbation.
Task 2 : Determine the mechanism, by which cell divisions and cell deaths fluidize the tumor.
Task 3 : Determine whether the cells active modulate their volume, after exposure to an external compressive stress and the role of the extracellular matrix in response to a compressive stress.
Giovanni Cappello (Giovanni.Cappello@univ-grenoble-alpes.fr) +33 (0)616 208 511