This position is now closed
Modelling of the mechanical interactions of a cell and an endothelium
An 18-month post-doctoral research position is available in an interdisciplinary
group within the Physics department of the University of Grenoble. The group
consists of researchers with a theoretical mechanics and applied mathematics
background, and has a day-to-day collaboration with a biology group specialized
in cancer cell biology (Institut A. Bonniot).
It focuses on mechanical aspects
of cell-cell interactions in the context of cancer metastasis.
Specifically, the project aims at understanding the mechanical modalities that
allow a tumour cell to migrate through a monolayer of endothelial cell, which is
a key process of metastasis known as transmigration. The modelling of this
process will be based on experimental measurement of both forces and displacements
using state-of-the-art experimental techniques. It will build up from a
rheological model and a numerical simulation finite element software currently
being developped within the group.
The successful applicant will have a background in mechanics, physics or applied
mathematics, and have had a prior experience of interdisciplinary work. Knowledge
in biophysics appreciated but not mandatory. Start date is flexible, between
1/1/2013 and 1/1/2014. Salary is 2048 euros per month, with national health
insurance included. The project will include overhead money for travel and
conferences. Grenoble
is an enjoyable, average-sized city in a valley of the
Alps, with convenient flight connections from
Lyon airport.
Contact: Jocelyn Etienne (modelling),
Jocelyn
Etienne
UJF-Grenoble
fr
,
Claude Verdier (experiments),
Claude
Verdier
UJF-Grenoble
fr
,
Alain
Duperray (biology),
Alain
Duperray
UJF-Grenoble
fr
.
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The TRANSMIG project at a glance: experimental investigation and modelling
of the mechanical processes involved in tumour cell transendothelial migration