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Sujets de Thèses

Dans cette rubrique quelques sujets de thèse financés proposés en ce moment au laboratoire. N’hésitez pas à contacter directement les chercheurs et à visiter le site de l’école Doctorale de Physique de Grenoble

Development, characterization and control of E. coli communities on an automated experimental platform

A PhD position funded by the Inria Project-Lab CoSy is open in project-team IBIS, which includes members of the Laboratoire Interdisciplinaire de Physique (LIPhy) of the University Grenoble-Alpes. The project includes data analysis and modelling tasks to be carried out at Inria, as well as experimental biology tasks carried out at LIPhy.

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Ecoulement de polymères en géométrie confinée.

Un fluide complexe microstructuré - comme une solution de polymère, un gel, une mousse ou une émulsion - s’écoulant en géométrie confinée va interagir avec les parois solides qui l’encadrent. Selon la nature des interactions entre les microéléments du fluide (molécules de polymère, bulles ou gouttes) et les parois, on peut éventuellement observer une déplétion ou une adsorption des microéléments à la paroi.

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Experimental and computational analysis of bacterial self-replicators

The growth of bacteria is fundamentally an optimization problem which consists in allocating resources to cellular functions so as to maximize growth rate or another fitness criterion. Simple ordinary differential equation models, called self-replicators, have been used to formulate this problem in the framework of optimal and feedback control theory, which has allowed a variety of observations in microbial physiology to be explained. The predicted resource allocation schemes of bacteria can be experimentally quantified using state-of-the-art techniques in molecular biology and biophysics.

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Protomembranes at the origin of life

Compartimentalization is a key point in the evolution of life, since it allowed to form cells, and define an inside and an outside. It allowed cells to create chemical gradients and harvest their energy. The origin of the first membranes which has been proposed to occur at hydrothermal vents still remains problematic, since high temperatures, which favor the efficiency of organic syntheses, also increase molecular motion of membrane lipids, leading to increased permeability, and decreased rigidity. Thus, under such fluctuating conditions, a protocell membrane is expected to have had limited stability and high permeability, which is in apparent contradiction with a possible origin of life in hydrothermal conditions.

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