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Neurons : The parallel dynamics of multiple ion channels revealed by optical imaging

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In neurons, electrical and calcium signals result from the synergistic simultaneous activity of several ion channel types. In the current issue of Journal of Neuroscience, researchers of the LIPhy and their international collaborators report a study where, for the first time, they reconstructed the parallel activity of diverse calcium and potassium channels during a physiological synaptic input in native neurons.

They studied the dendritic depolarisation produced by the climbing fibre synaptic potential in cerebellar Purkinje neurons using a cutting-edge imaging approach developed in our institute. Then, they used computer simulations from a detailed model including all relevant channels to match experimental data and they extrapolated the parallel activity of all channels. This approach will be used to investigate other neuronal types to explore the physiological behaviour of native channels and the pathologies caused by channel dysfunctions named “channelopathies”.

Membrane potential and calcium signal associated with a climbing fibre synaptic potential from a site of a Purkinje neuron dendrite outlined by a cylinder. The larger cylinder below illustrates the physical model containing all activated channels and other mechanisms contributing to the imaged signals.
Membrane potential and calcium signal associated with a climbing fibre synaptic potential from a site of a Purkinje neuron dendrite outlined by a cylinder. The larger cylinder below illustrates the physical model containing all activated channels and other mechanisms contributing to the imaged signals.

Voir en ligne : Two Distinct Sets of Ca2+ and K+ Channels Are Activated at Different Membrane Potentials by the Climbing Fiber Synaptic Potential in Purkinje Neuron Dendrites. Ait Ouares K, Filipis L, Tzilivaki A, Poirazi P, Canepari M. J Neurosci. 2019 Mar 13 ;39(11):1969-1981.