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Accueil > Recherche > Séminaires & Conférences > Séminaires au Laboratoire

Séminaires Invités

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Séminaires donnés par des invités extérieurs au LIPhy.

Ce sont des séminaires généraux qui s’adressent à tous les membres du LIPhy. Par conséquent, l’introduction, la plus large possible, y joue un rôle important.

Les séminaires durent environ 1heure dont 15mn accordées aux questions. Ils ont lieu les lundis à 14h, en salle de conférence du laboratoire au deuxième étage. La langue des séminaires est en général l’anglais.

L’accès au laboratoire peut-être obtenu en contactant le secrétariat.

Agenda

  • Lundi 21 octobre 14:00-15:30 - Daria Tsvirkun - Moscow State University, Russia

    Endothelialized Microchannels as In Vitro Model of Small Vessels

    Résumé : Microfluidic technology highly developed in physics is now widely used to create tools for cell biology. A variety of bioassays and investigations can be carried on in microfluidic systems where living cells can be cultured : cell migration and interaction, cancer cell invasion, drug delivery assays, wound healing, angiogenesis, thrombosis, studies of blood flow and shear stress etc.
    The vascular endothelium is considered as a complex organ, which is responsible for the dynamic control of vessel functions. The endothelium is continuously exposed both to shear stress and changes in pressure, including rhythmic fluctuations due to heart beating and to the signals from surrounding tissues. The luminal surface of endothelial cells is coated by gel-like endothelial glycocalyx layer. It is currently known that its main functions include modulation of vessel permeability to water and macromolecules ; mechanotransduction of fluid shear stress and pressure to the endothelial cytoskeleton and regulation of shear stress-mediated NO production ; regulation of red and white blood cells’ adhesion as well as modulation of the inflammatory response via binding of inflammatory factors.
    In order to test endothelial cells’ behavior in a three dimensional dynamic model reproducing the influence of physiological flow and shear stress as an important part of “everyday life” of the endothelium, we developed and tested a “microvasculature-on-a-chip” microfluidic device and performed several tests to verify its possible biomedical applications. We confirmed possibility to implement our chip to study changes in endothelium permeability in order to study capillary leak syndrome, and the endothelial remodeling in response to changes in glucose concentration like what happens during diabetes mellitus disease. We shall show that our system presents a promising tool to thoroughly study endothelial cells and its interaction with blood.



    contact : Chaouqi Misbah

    Lieu : LIPhy, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères


  • Lundi 4 novembre 14:00-15:30 - Ibrahim CHEDDADI - TIMC, CNRS – Univ. Grenoble Alpes

    Coupling Water Fluxes and Wall Mechanics in a Physical Model of Plant Tissues

    Résumé : Plants morphogenesis relies mostly on oriented divisions and growth heterogeneities. For instance, the lateral organs (future branches or flowers) are initiated by small bumps at the periphery of the Shoot Apex Meristem thanks to a local increase in growth rate ; at a smaller scale, cell-to-cell heterogeneity is also observed but its origin and function are still not well understood. Cellular growth is based on osmosis that attracts water inside the cells, and wall synthesis that allows cells to grow without increasing wall tension and hydrostatic pressure. We propose a multicellular model that couples these two phenomena and show that it leads to unexpected emergent properties at tissue level, in particular the amplification of growth heterogeneities. At cellular level, we are able to predict and interpret local measurements of pressure and growth rate in two different experimental conditions.



    contact : Jocelyn Etienne

    Lieu : LIPhy, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères


  • Lundi 18 novembre 14:00-15:30 - Matvey Morozov

    LIPHY Seminar

    Résumé :



    contact : Salima Rafaï

    Lieu : LIPhy, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères


  • Lundi 25 novembre 14:00-15:30 - Pierre-Antoine Bouttier

    LIPHY Seminar

    Résumé :



    contact : Philippe Beys

    Lieu : LIPhy, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères


  • Lundi 16 décembre 14:00-15:30 - Guillaume Parry - SIMAP, Grenoble-INP/UGA/CNRS

    LIPHY Seminar

    Résumé :



    contact : Jocelyn Etienne

    Lieu : LIPhy, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères


  • Lundi 17 février 2020 14:00-15:30 - Knut Drescher - MPI Marburg

    LIPHY Seminar

    Résumé :



    contact : Jocelyn Etienne

    Lieu : LIPhy, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères


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