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18 septembre 2017: 1 événement

  • Séminaires Invités

    Lundi 18 septembre 14:00-15:30 - Grégoire MICHAUX - Institut de Génétique et Développement de Rennes

    Shape Acquisition During C. Elegans Embryogenesis

    Résumé : Acquisition of shape through growth and morphogenesis is an essential process in the life of all complex organisms. To address this question we investigate the acquisition of a larval shape using the nematode C. elegans as a model organism. This morphogenetic event can be described as the transformation of an ovoid group of about 500 cells into a 4-fold elongated cylinder without cell division nor cell intercalation, and within an almost constant volume. Embryonic elongation is first controlled by contractions of disorganised cytoskeleton filaments in two rows of lateral cells. Later muscle contractions in the antero-posterior axis will generate a tissue-wide tension relayed by dorsal and ventral cells leading to a reorganisation of cytoskeleton filaments in lateral cells and further elongation of the embryo. We and others have identified many molecular components of this trans-tissular biomechanical pathway controlling shape acquisistion via establishment of a planar polarity. We now wish to better understand the relationships between tissue-wide and subcellular mechanical deformations leading to morphogenesis, to generate new models and hypotheses which will then be tested in vivo.



    contact : Jocelyn Étienne

    Lieu : LIPhy, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères

    En savoir plus : Séminaires Invités