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11 décembre 2017: 1 événement

  • Séminaires Invités

    Lundi 11 décembre 14:00-15:30 - Boris GUIRAO - "Polarity, Division & Morphogenesis" Lab Unit of Genetics and Developmental Biology (UMR3215/U934) Institut Curie, Paris

    From Cells to Tissues : Unified Characterization of Epithelial Tissue Development

    Résumé : Understanding the mechanisms regulating development requires a quantitative characterization of cell behaviors such as cell divisions, rearrangements, size and shape changes, and death. We developed a multiscale formalism that relates the characterizations of each cell behavior to tissue growth and morphogenesis. Having validated this formalism on computer simulations, we quantified separately all morphogenetic events in the Drosophila dorsal thorax and wing pupal epithelia to obtain comprehensive statistical maps linking cell and tissue scale dynamics. While globally cell shape changes, rearrangements and divisions all significantly participate in tissue morphogenesis, locally, their relative participations display major variations in space and time. By blocking division we analyzed the impact of division on rearrangements, cell shape changes and tissue morphogenesis. Finally, by combining the formalism with mechanical stress measurement, we evidenced unexpected interplays between patterns of tissue elongation, cell division and stress. Our formalism provides a novel and rigorous approach to uncover mechanisms governing tissue development.



    contact : Martial Balland

    Lieu : LIPhy, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères

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