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5 février 2018: 1 événement

  • Séminaires Invités

    Lundi 5 février 14:00-15:30 - Edouard HANNEZO - IST Austria, Physical principles in biological systems, Vienna

    Self-Organizing Principles in Branching Morphogenesis

    Résumé : The morphogenesis of branched organs remains a subject of abiding interest for physicists and biologists alike. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their size, network topology, and spatio-temporal patterning, are encoded. Here, we show that, in mouse mammary gland, kidney, and human prostate, these features can be explained quantitatively within a single unifying framework of two-species branching and annihilating random walks. These results show that complex branched epithelial structures develop as a self-organized process analogous to a Fisher-KPP pulse, reliant upon a strikingly simple but generic rule, without recourse to a rigid and deterministic sequence of genetically programmed events.

    contact : Pierre Recho

    Lieu : LIPhy, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères

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