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2 juillet 2018: 1 événement

  • Séminaires Invités

    Lundi 2 juillet 2018 14:00-15:30 - Wolfram Liebermeister - Unité MaIAGE, Institut National de la Recherche Agronomique, Jouy-en-Josas

    Resource Allocation in Kinetic Models of Cell Metabolism

    Résumé : Metabolic fluxes in cells are often assumed to reflect an economical use of enzymes. To apply this principle of "minimal enzyme cost" to metabolic modelling and to study its biological consequences, I consider two types of computational models : models in which the metabolic fluxes are predefined and metabolite concentrations are optimised in order to minimise enzyme cost ; and models in which the fluxes are also optimised.
    In the first case, optimal enzyme and metabolite levels can be computed by solving a convex optimization problem. The formalism highlights the close relation between enzyme demand and reaction thermodynamics.
    In the second case, we obtain a nonlinear version of flux balance analysis, a method commonly used in flux prediction. The optimal fluxes can be determined be screening all elementary flux modes, a well-defined set of maximally sparse flux distributions.
    Altogether, we obtain a tractable method for predicting optimal fluxes, metabolite levels, and enzyme levels in models of central metabolism.

    contact : Johannes Geiselmann

    Lieu : LIPhy, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères

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