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29 avril 2019: 1 événement

  • Séminaires Invités

    Lundi 29 avril 14:00-15:30 - Ignacio Izeddin - Institut Langevin, ESPCI Paris, CNRS, PSL University

    Molecular Dynamics, Target Search and Nuclear Organization : A Single-Molecule Approach

    Résumé : Gene regulation relies on highly mobile transcription factors (TFs) exploring the nucleoplasm in search of their targets. While many studies have focused on how fast TFs diffuse, important questions remain on how these regulatory factors explore the nuclear environment in search of their targets, and how their exploration strategy affects the kinetics of transcriptional regulation.
    Using single-molecule imaging techniques, we have studied the organization of nuclear components, the dynamics of TFs, and the relationship between the two. I will present results on the different exploration strategies performed by the proto-oncogene c-Myc and the positive transcription elongation factor-b (P-TEFb). We found that c-Myc is a global explorer of the nucleus while P-TEFb is a local explorer that oversamples its environment. The geometry-controlled kinetics of TFs target-search illustrates the influence of nuclear architecture on gene regulation, and has strong implications on how proteins react in the nucleus and how their function can be regulated in space and time.
    I will also introduce the Complex diffusion analysis challenge that we are currently organizing. Our goal is to foster the development of new state-of-the-art analysis algorithms. We aim at providing a unified data benchmark based on a set of biologically and physically relevant metrics in order to compare the diffusion analysis software available for the community.

    contact : Salima Rafaï

    Lieu : LIPhy, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères

    En savoir plus : Séminaires Invités