Research project TRANSMIG

Transendothelial migration of cancer cells

 ANR Transmig

Équipe Dynamique des Fluides Complexes
Laboratoire Interdisciplinaire de Physique (LIPHY)
CNRS & Université Grenoble Alpes
Équipe 8 - Immunologie analytique des pathologies chroniques
Institut Albert Bonniot (IAB)
Inserm & Université Grenoble Alpes
Contact: Claude dot Verdier at UJF-Grenoble dot fr

In brief

People

Open position: Masters internship
We are looking for a highly motivated Masters student to carry modelling work within the group. PhD thesis to follow. Read more.

In IAB:

  • Alain Duperray, Inserm researcher
  • Olivier Blond, Inserm technician
  • Vinoth Sundar Rajan, PhD student (2013–)
In LIPHY:
  • Claude Verdier, CNRS researcher
  • Guido Vitale, post-doctoral researcher
  • Jocelyn Étienne, CNRS researcher
  • Laure Laforgue, PhD student (2013–)
  • Mahamar Dicko, PhD student (2011–)
  • Mickaël Betton, Univ. J. Fourier engineer
  • Richard Michel, CNRS engineer
  • Sigolène Lecuyer, CNRS researcher
  • Valérie Laurent, Univ. J. Fourier lecturer
  • Yara Abidine, PhD student (2012–)
Alumni:
  • Baptiste Bedessem, Masters student in LIPHY, 2012.
  • Valentina Peschetola, PhD student in LIPHY, 2008–2011.

Current funding

ANR project, 2013-2016

At a glance

Methods

Combined experimental and numerical technique

Traction force microscopy

R. Michel, C. Verdier, V. Laurent, J. Étienne, G. Vitale


We have expertise in TFM, and have contributed to the improvement of the practical use of the adjoint method proposed by our collaborator Davide Ambrosi.

We have published a mathematical study of the bases of TFM [R. Michel et al., 2013] and a comparison of this method with the widely-used FTTC [R. Michel et al., 2012]. We have exploited it in the study of the traction forces of cancer cells [V. Peschetola et al., 2011, V. Peschetola et al., 2013].

Numerical technique

Fluid-interface problems

M. Dicko, J. Étienne

In a collaboration with Pierre Saramito, two members of the project develop a numerical technique specialised in fluid-interface problems.

This method is efficient to solve 3D problems involving:

  • Fluid/thin structure interactions, such as medium or cytosol/actomyosin cortex interactions.
  • Surfacic partial differential equations, such as convection-diffusion of binding molecules along the plasmic membrane.
This method is currently at the stage of development. It will then be applied to relevant biological problems.

For more informations, see M. Dicko's poster, presented at SMAI 2013 conference.